The New Medication DAPOXETINE: Review of Research, User Experiences

How Effective Is Dapoxetine
And What Are The Side Effects?

Dapoxetine is officially available in some European countries ... plus New Zealand
Real User Experiences, Research Facts, Alternatives
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Here's What Is Claimed...

DAPOXETINE is the first medication specially developed to delay ejaculation. Taken 1-2 hours prior to sex, Dapoxetine research claims increases of ejaculation times by about 2-4 times, depending on the dose. The effect will start about 1 hour after taking the tablet, and last up to 6 hours. 

Mens' experiences of dapoxetine verify this, but there are some exceptions. Dapoxetine is claimed to be safe, can be used on-demand, and is usually more reliable than herbs, sprays or other medications since the dose can be precisely calculated to create the desired effect of ejaculatory control. Experience also verifies this.

Ejaculatory control is very important for a good sexual experience for both partners. In particular most women require continuous thrusting for at least several minutes to achieve a vaginal orgasm, even if they are already sexually primed with foreplay.

Most men get immediate and satisfying increase of ejaculation control and a more satisfied partner, but some men do NOT like the effects of dapoxetine.

Please continue below...

How serious is your premature ejaculation?

The old understanding of Premature Ejaculation was that it was caused by habits such as masturbating quickly. The behavioural treatments then followed including the squeeze technique and the stop-start technique. These treatments may work initially but the results do not last in the vast majority of cases.

New research shows that there is a physical basis to premature ejaculation which is at least partly genetic (inherited).

Ejaculation time is formally called IELT (intra vaginal latency time) which basically means the time after penetration before ejaculation. Rapid ejaculation is just the expression, as found in other variables such as body weight and height, of a natural range of ejaculation times.

Most findings one ejaculation times are self-reports and are unreliable and inflated. Men usually overestimate the amount of time they last.

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Most Reliable Findings On Actual IELT

The first (left hand) graph below shows a typical range of ejaculation times, measured by a stopwatch, for a random group of 500 men. The mean time is about 5 minutes shown by the yellow line.

The second graph (right) shows the ejaculation times of dozens of men who sought treatment for premature ejaculation, as measured by a stopwatch. The vast majority of these men ejaculated in less than 1 minute, indicated by the yellow line. So for men with premature ejaculation who are actively seek treatment, the vast majority ejaculate in seconds, not minutes.

Research: How Dapoxetine Actually Works

Men who ejaculate fast have been found to be low in an inhibitory body chemical called serotonin. Scientists have also shown that levels of body serotonin is an important factor in the rapidity of ejaculation. This is particularly true in a subset of men with premature ejaculation who have had the condition from birth and in all circumstances, called lifelong premature ejaculation.

Dapoxetine safely and rapidly boosts the ejaculation-delaying chemical serotonin: it does this by preventing or delaying the breakdown of serotonin in the body, meaning that levels remain higher. This, in turn, leads to its ejaculation-delaying effect.

Furthermore, dapoxetine is  safer than other anti-depressant medications that increase serotonin, because it does not allow  serotonin levels to remain high, like other similar drugs (technically called SSRIs). Consistently high levels of serotonin will reduce sex drive and cause sleepiness, as well as other negative effects that come from changing the body's overall chemistry in the long term.

A large number of clinical studies on dapoxetine, which included several large trials of men, have shown that it consistently increased ejaculation.

These studies were done on men who typically had an IELT of less than one minute.

Dapoxetine also lengthens the IELT of men who have a longer ejaculation time than these study groups and anecdotal reports suggest the effect on lengthening time to ejaculation is similar in a percentage terms.

Dapoxetine lengthened normal ejaculation time by about 300% at a dose of 30mg taken one hour before intercourse, and about 400% at a dose of 60mg.

The graph below shows the effect of control group, placebo group, 30mg and 60mg dapoxetine group across five large studies. The effects on lengthening ejaculation were consistent. The ejaculation delaying effect at a higher dose of 60mg is slightly more, but there are also more side effects at the higher dose.

It is important to note that dapoxetine is not a cure for PE. It needs to be taken on an as-needed to continue the effects.

However, several men have reported that using dapoxetine gives them a sense of control and some 'breathing space' to become more aware of their body's responses, and therfore more able to learn how to manage their ejaculation response using other methods (sign up to get more information).

This means that they are eventually able to reduce the dose or even just to use it in high-stakes situations e.g. with a new partner.

 
What Do Researchers Find?

Lifelong rapid ejaculation is not an acquired disorder caused by initial hurried intercourse, as suggested by Masters and Johnson. Instead, rapid ejaculation is postulated to be part of a normal biological variability of ejaculation latency time (IELT) in men.

Based on psychopharmacological studies there is evidence that premature ejaculation is related to a diminished serotonergic neurotransmission. (i.e. PE is a physical variable)

Controlled trials with selective serotonin reuptake inhibitors (SSRIs) have repeatedly shown their efficacy.

Disadvantages of conventional SSRIs include their delayed onset of action and the reduction of libido and erection strength. In contrast Dapoxetine has a rapid onset of action of approximately 1.5 hours and a short half-life and the normal dose of 30 or 60mg is taken 1-3 hours before intercourse.

Sexual side effects are infrequent with dapoxetine. On demand dapoxetine has no significant adverse effects on libido (< 1%) or erection (< 4%), presumably because it does not persist in the body and thus there are no adaptive changes.

Unlike other SSRIs, dapoxetine is effective on the first dose. These properties make dapoxetine suitable for the on-demand treatment of PE.

Dapoxetine significantly increased the IELT compared to placebo (P<0.0001). 

The most common and a dose-dependent adverse effect with dapoxetine is nausea. Even so, nausea after dapoxetine is mainly mild, transient and related to the presence of dapoxetine in the body.

 

What Are The Side Effects?

Every medication has side effects. Dapoxetine is no exception although the side effects could be classified as low compared with many drugs. It belongs to a class of medications called SSRIs that is relatively well understood, and the research trials showed that about 10% of men had some side effects, mainly nausea. The level of side effects was dose dependent (more at higher doses).

About 5% of men elected not to use dapoxetine due to the level of side effects but, overall, researchers concluded that dapoxetine is well-tolerated. Note that almost any medication (and even a placebo) will cause some side effects.

How Reliable Is Dapoxetine ?

No. Again this is typical and any claim that a procedure will cause 100% success is basically lying. There are about 5-10% of men, based on anecdotal evidence, who have only minor increases in IELT at the 30mg dose. The reason is not fully understood.

But more than 90% of men do benefit, some dramatically so. And this is a far higher percentage than any evidence shows for behavioral techniques. 

 
The Experiences of Men Using Dapoxetine..

I've used dapoxetine ... I'm a college student and I had never had a good sexual experience before using it.  I'm not going to say I had the control of a pornstar, but I was more than adequate and my partners have positive comments.  I highly recommend Dapoxetine! David J

.how about the "30 second man". I used to be so embarrassed, I used to dread going into the bedroom with my girlfriend: I was a terrible lover..........well, let me tell you some facts about dapoxetine. WOW...I had my doubts at first, but this was the real thing, the best thing I ever got my hands on. I was soooo impressed with myself: I could actually last and give her the orgasms that she used to lie about. Eldon L.

It delayed my ejaculation time by 3 minutes the first time I tried it: for me, it was like an hour. I wished I had known about this years ago, ....all the years of stress and worry about the PE problem, and avoiding sex all together sometimes because of the embarrassment I suffered. Tom L

I've been using Dapoxetine and it works for me. Dick B

I tried Dapoxetine. It worked ..... My first experience was awesome; I was able to last for 7 minutes; before taking it I was able to last only for 2-3. My wife also sees a difference as well, because I can keep going longer, she is able to get turned on enough to reach orgasm. Great stuff!
Mike B.

Note: The response to dapoxetine seems to vary for different men, with some men requiring the lower dose (30mg) and others requiring the higher dose used in most research (60mg). Doses higher than this cause more side effects such as nausea.

 

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Disclaimer

This website is an information site reporting on health prescription drugs. The information provided here is for general information only and is not meant to replace the advice of a trained medical professional. While we endeavor to provide accurate information, we rely on the reports of other parties to do so, including published medical research reports. We have no ability to operate a pharmacy and hence, cannot take orders for the products mentioned here. It is the responsibility of the patient to determine the accuracy and authenticity of a pharmacy before placing an order. We make no warranties or representations of any pharmacy mentioned on the site or in subsequent communications. We do not condone the illegal use of any drug. Nor are we responsible for any effects of any medication mentioned on this site. You should consult your doctor before taking any medication. Any testimonials on this site may not be typical of the average user and some men may experience no benefit from dapoxetine, or alternatively suffer side effects from so doing.


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